海外

Postdoctoral Fellow : Iowa City, United States
Employer: University of Iowa Carver College of Medicine
Website: http://www.int-med.uiowa.edu/divisions/cardiology/Directory/IsabellaGrumbach.html
Location: 2270-A CBRB, 285 Newton Road, Iowa City, IA, United States
Type: Postdoctoral
Posted: March 19, 2012
Expires: May 01, 2012

job description

We are recruiting a talented and motivated postdoctoral trainee. The Grumbach lab is affiliated with the Iowa City VA Medical Center and located at the University of Iowa that boasts a highly interactive and multidisciplinary faculty in cardiovascular research. The University of Iowa has a long track record of excellence in cardiovascular research. Numerous opportunities for cutting-edge, innovative collaborations exist in this rich scientific environment. The current interests of the lab are the regulation of smooth muscle proliferation in neointima formation and blood pressure regulation by calcium-/calmodulin-dependent kinases.

Candidates with a PhD in Biology, Biochemistry, or Pharmacology, or a closely related field should apply. Experience with the following is important: biochemistry and molecular biology, imaging experience, primary vascular cell and tissue culture, in vivo analysis of small mammals, and functional studies of intact blood vessels. The successful candidate would continue to pursue projects that have yielded promising preliminary data. Previous experience in vascular biology is desired. Excellent spoken and written English is required. This position is available on June or July 1. Applications with a full CV, references and a cover letter should be submitted by email to Dr. Isabella Grumbach (isabella-grumbach@uiowa.edu).

Representative publications include:
1. Oxidation of CaMKII determines the cardiotoxic effects of aldosterone.
He BJ, Joiner ML, Singh MV, Luczak ED, Swaminathan PD, Koval OM, Kutschke W, Allamargot C, Yang J, Guan X, Zimmerman K, Grumbach IM, Weiss RM, Spitz DR, Sigmund CD, Blankesteijn WM, Heymans S, Mohler PJ, Anderson ME.
Nat Med. 2011 Nov 13;17(12):1610-8.
PMID: 22081025

2. The multifunctional Ca2+/calmodulin-dependent kinase II delta (CaMKIIdelta) controls neointima formation after carotid ligation and vascular smooth muscle cell proliferation through cell cycle regulation by p21.
Li W, Li H, Sanders PN, Mohler PJ, Backs J, Olson EN, Anderson ME, Grumbach IM.
J Biol Chem. 2011 Mar 11;286(10):7990-9.
PMID: 21193397

3. Calmodulin kinase II is required for angiotensin II-mediated vascular smooth muscle hypertrophy.
Li H, Li W, Gupta AK, Mohler PJ, Anderson ME, Grumbach IM.
Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H688-98.
PMID: 20023119

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