Job Title:  Postdoc Nutrient sensing, TOR, dietary restriction and aging
Job Number:  7044321
Date Posted:  06/22/2011
Application Deadline:  Open Until Filled

Job Description
Postdoctoral position available -Kapahi Laboratory
Nutrient sensing,TOR, dietary restriction and aging

The focus of the Kapahi Laboratory is to identify and characterize the genetic pathways that mediate effects on lifespan, age-related diseases and metabolism. This is being achieved by using an interdisciplinary approach combining genetic, biochemical and genomic techniques in invertebrate model systems D. melanogaster, C. elegans, and human cells. In particular the lab is following their discoveries that TOR pathway, modulation of mRNA translation, mitochondrial function and ER stress, modulate lifespan. The broader significance of this research is to help uncover the role of nutrition in the etiology of age-related human diseases like diabetes, obesity, cancer and neurodegeneration. The lab is interested in developing models of age-related diseases using invertebrate and cell culture model systems. The candidate will receive training in specific area(s) of research with the aim of progressing towards an independent career. For more questions regarding this position please e mail Pkapahi@buckinstitute.org and check the lab website at http://www.buckinstitute.org/kapahiLab

Selected publications
1. Kapahi P, Rogers A, Chen D. Katewa SD, Li P, Kockel L. ‘With TOR, less is more: The emerging role of the TOR pathway in aging.’ In press Cell Metabolism
2. Kapahi P, Rogers A, Chen D. Katewa SD, Li P, Kockel L, 2010. ‘With TOR, less is more: The emerging role of the TOR pathway in aging.’ Cell Metabolism, 2010
3. Zid BM, Rogers A, Katewa SD, Au Lu T, Benzer S, Kapahi P. 4E-BP modulates lifespan and mitochondrial translation upon dietary restriction in Drosophila. Cell (2009).
4. Chen, D; Thomas E L; Kapahi P. HIF-1 Modulates Dietary Restriction-mediated Lifespan Extension via IRE-1 in C. elegans. PLOS Genetics; 2009
5. Chen D, Pan KZ, Palter JE, Kapahi P. Longevity determined by developmental arrest genes in Caenorhabditis elegans. Aging Cell, 2007
6. Pan KZ, Palter JE, Rogers AN, Olsen A, Chen D, Lithgow GJ, Kapahi P. Inhibition of mRNA translation extends lifespan in C. elegans. Aging Cell 2007
7. Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, & Benzer S. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol. 2004
Contact:  
Buck Institute for Research on Aging
Novato, CA
United States
Email: Send your resume/CV

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