Job Title:  Postdoctoral Fellow
Job Number:  4009475
Date Posted:  06/21/2011

Job Description
POSITION: Postdoctoral fellow
IMMEDIATE SUPERVISOR: Principal Investigator

SUMMARY:
Seeking a postdoctoral fellow to join a laboratory focusing on molecular mechanisms of resistance to antiangiogenic agents, with a specific attention paid to the effects of antiangiogenic agents on the tumor endothelium. The principal investigator is a medical oncologist and physician scientist with funding from the National Institutes of Health (PN1), private industry and philanthropy.
The laboratory primarily employs both human tissue and other samples taken from tissue rich clinical trials, small animal (mouse) models using antiangiogenic agents, and in vitro experiments. The ideal candidate will have experience investigating endothelial biology, and have experience with human tumor xenografts. The candidate should also be proficient in molecular and cellular biology techniques, particularly those that relate to the study of intracellular signaling pathways, receptor biology, and tissue analysis, preferably with multispectral image analysis tools.
This position requires a driven and motivated individual. The candidate should welcome the challenge of exploring new techniques and new ideas relating to tumor biology.

ESSENTIAL FUNCTIONS:
• Hypothesis generation and experimental planning
• Comprehensive understanding and review of relevant literature
• Analysis of in vivo murine models of angiogenic therapy resistance
• Analysis of human tissue from patients treated with antiangiogenic agents
• Flow cytometry
• Study of cell signaling
• Western blotting
• Immunohistochemistry and ideally have experience with multispectral tissue analysis systems including Ariol and Vectra
• Cloning
• Cell culture
• Quantitative RT-PCR
• Preparation of figures and drafts of manuscripts for publication
• Supervision of more junior members (e.g. graduate students) in the laboratory

EDUCATION:
Required: M.D. or Ph.D.

EXPERIENCE:
Required: Minimum of two years related experience
M. D. Anderson Cancer Center is an equal opportunity employer and does not discriminate on basis of race, color, national origin, gender, sexual orientation, age, religion, disability or veteran status except where such distinction is required by law. All positions at The University of Texas M. D. Anderson Cancer Center are security sensitive and subject to examination of criminal history record information. Smoke-free and drug-free environment.
Contact:  Deborah Ogutu
GU Medical Oncology
The University of Texas M. D. Anderson Cancer Center
Unit 1374
1155 Pressler
Houston, TX 77030
United States
Fax: 713-745-1625
Email: Send your resume/CV
Employer's Web Site:  Visit employer's website

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