Employer: Paterson Institute for Cancer Research
Website: http://www.paterson.man.ac.uk
Location: Manchester, United Kingdom
Type: Postdoctoral
Posted: June 13, 2011
Expires: July 18, 2011
Jobs by tag(s): paterson institute for cancer research postdoctoral scientist immunology manchester united kingdom cell biology biological sciences microbiology paterson institue for cancer reseach cruk postdoctoral immunology molecular biology biochemistry animal models
Requisition number: PI / 11 / 16
Science jobs from Paterson Institute for Cancer Research: job description

Postdoctoral Scientist – Immunology

• Job Ref: PI/11/16
• 3 year fixed-term position
• Salary in the range of £28,500 – £38,000 dependent upon qualifications and experience

The Paterson Institute is a leading cancer centre of excellence core-funded by Cancer Research UK and is an Institute of The University of Manchester.

We have established that the 5T4 glycoprotein is required for optimal functional cell surface expression of the chemokine receptor CXCR4 and CXCL12 mediated chemotaxis in mouse embryonic cells (1). We have now shown that in some human tumour cells, 5T4 expression is necessary for CXCR4/CXCL12 chemotaxis. The regulation of functional chemokine receptor expression associated with 5T4 molecules is a means to control different biological responses to the chemokine CXCL12 advantaging the growth and spread of a 5T4 positive tumour from its primary site. Such a possibility is consistent with data from a retrospective gene expression profiling of diagnostic B-ALL bone marrow samples which revealed significantly higher 5T4 transcript levels were associated with a subset of patients with high risk of relapse. A key goal is to define the mechanisms regulating the expression of 5T4 in this lineage and its biological consequence in vitro and in vivo. This will begin with microarray and/or proteomic comparisons of naturally 5T4+ and –ve sub-lines of established B-ALL lines. Xenograft models are available to investigate the role of 5T4 molecules in tumour spread in vivo (2). The wider goal is to define the 5T4 dependent biological responses controlling normal and tumour cell function.

You should preferably have a strong background in molecular biology, biochemistry and animal models.

Informal enquires to Peter L Stern, pstern@picr.man.ac.uk or tel: 0161 446 3127

1. Southgate, TD, McGinn OJ, Castro FV, Rutkowski AJ, , Al-Muftah M, Marinov G, Smethurst GJ, Shaw D, Ward CM, Miller CJ, and Stern PL. (2010). CXCR4 Mediated Chemotaxis is Regulated by 5T4 Oncofetal Glycoprotein in Mouse Embryonic Cells. PLoS ONE 5(4): e9982. doi:10.1371/journal.pone.0009982.
2. Holland M, Castro FV, Alexander S, Smith D, Liu J, Walker M, Bitton D, Mulryan K, Ashton G, Blaylock M, Bagley S, Connolly Y, Bridgeman J, Miller C, Krishnan S, Dempsey C, Masurekar A, Stern P, Whetton A, Saha V. RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia. Blood. 2011 May 23. [Epub ahead of print]

To apply for this position please visit our website: http://www.paterson.man.ac.uk

For applicants who are unable to download this information from our website, please contact HR department on 0161 446 3231, email: jobs@picr.man.ac.uk to have this information sent by post.

Closing date: 18th July 2011.

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